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Symbol
Name
ID
Egln1
egl-9 family hypoxia-inducible factor 1
MGI:1932286
Phenotype annotations related to cardiovascular system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations

Mouse Phenotypes
cardiovascular system phenotype
abnormal blood vessel morphology
abnormal capillary morphology
abnormal capillary branching pattern
abnormal kidney vasculature morphology
abnormal liver vasculature morphology
dilated liver sinusoidal space
liver vascular congestion
abnormal lung vasculature morphology
pulmonary vascular congestion
increased angiogenesis
blood vessel congestion
dilated vasculature
abnormal myocardium layer morphology
increased myocardial fiber size
myocardial fiber degeneration
abnormal trabecula carnea morphology
thin ventricle myocardium compact layer
delayed heart development
abnormal heart morphology
abnormal coronary vessel morphology
increased heart atrium size
abnormal interventricular septum morphology
increased heart weight
enlarged heart
abnormal heart ventricle morphology
abnormal heart left ventricle morphology
cardiac interstitial fibrosis
dilated cardiomyopathy
abnormal blood viscosity
hypervolemia
cardiac ischemia
hemorrhage
decreased ventricle muscle contractility
decreased cardiomyocyte apoptosis
abnormal response of heart to induced stress
increased response of heart to induced stress
abnormal response to cardiac infarction
decreased myocardial infarct size
congestive heart failure
Availability Mouse Genotype
Egln1Gt(RRG405)Byg/Egln1Gt(RRG405)Byg *
Egln1tm1Fong/Egln1tm1Fong
Egln1tm1.1Brei/Egln1tm1.1Brei
Myl2tm1(cre)Krc/Myl2+  (conditional)
*
Egln1tm1.1Brei/Egln1tm1.1Brei
Tg(CD68-icre)1Bwlx/0  (conditional)
Egln1tm1Kael/Egln1tm1Kael
Tg(CAG-cre/Esr1*)5Amc/0  (conditional)
Egln1tm1Kael/Egln1tm1Kael
Tg(Myh6-cre)2182Mds/0  (conditional)
Egln1tm2.1Fsl/Egln1tm2.1Fsl
Pax3tm1(cre)Joe/Pax3+  (conditional)
Egln1tm2.1Fsl/Egln1tm2.1Fsl
Tg(Cdh5-cre)7Mlia/0  (conditional)
Egln1tm2Fong/Egln1tm2Fong
Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory